Apolipoprotein Mimetics in the Management of Human Disease by G.M. Anantharamaiah, Dennis Goldberg

By G.M. Anantharamaiah, Dennis Goldberg

This finished ebook offers not just the levels within the improvement of this detailed and really expert box but in addition updates at the present country of analysis and improvement of apolipoprotein mimetics as healing modalities for varied lipid-mediated issues. The ebook involves eleven chapters all written by way of major scientists from well-reputed laboratories within the united states. After an advent via Dr. Godfrey Getz, Professor of drugs on the collage of Chicago and the affiliate Editor of the magazine Lipid examine, the booklet offers a narration of ways a concept can result in the invention of remedy modalities to a number of devastating ailments reminiscent of diabetes, Alzheimer’s illness, arthritis; bronchial asthma; atherosclerosis, power rejection of transplanted hearts and cancer.

Present cures for many of those ailments should not sufficient. utilizing the types of 2 lengthy anti-atherogenic and anti inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) brief mimetic peptides of 18 to twenty-eight amino acid residues in size, that are produced both synthetically or genetically in fit for human consumption fruit and veggies, were proven to exert profound organic results in loads of animal types of diseases.

The e-book additionally provides novel rules, hugely unforeseen mechanisms of motion in animal versions or even in preliminary medical experiences in people, which can result in extra advancements in uncomplicated and scientific examine in organic technological know-how. all of the chapters are written by means of specialists of their respective fields who've contributed immensely to the literature. this can be the 1st compendium of this becoming box awarded within the type of a book.

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The first is based on maximizing the ability of these peptides to promote cholesterol efflux by the reverse cholesterol transport (RCT) pathway (Fig. 1). The second strategy is based on optimizing one of the other beneficial features of ApoA-I and HDL, such as its ability to bind and sequester proinflammatory oxidized lipids. In this chapter, we will first review how ApoA-I and HDL mediate cholesterol efflux and participate in the RCT pathway. Next, we will review all of the apolipoprotein mimetic peptides undergoing drug development listed in Table 1, with an emphasis on those features related to the cholesterol efflux properties of these peptides.

Subsequent to the report by Chattopadhyay et al. (2013), Zhao et al. (2014) reported that an apoA-I mimetic peptide with a completely different structure from the 4F, 5F to 6F peptides was equally effective when administered by injection or given orally despite the inability to detect peptide in the plasma after oral administration and the findings of very high peptide plasma levels after injection. These findings suggested that the site of action of multiple apoA-I mimetic peptides with completely different structures might be in the intestine regardless of the route of administration (Wool et al.

Proteins 8:103–117 Segrest JP, Jones MK, De Loof H, Brouillette CG, Venkatachalapathi YV, Anantharamaiah GM (1992) The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J Lipid Res 33:141–166 Segrest JP, Garber DW, Brouillette CG, Harvey SC, Anantharamaiah GM (1994) The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins. Adv Protein Chem 45:303–369 Segrest JP, Jones MK, Klon AE, Sheldahl CJ, Hellinger M, De Loof H, Harvey SC (1999) A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein.

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