Antibody-Drug Conjugates: Fundamentals, Drug Development, by Kenneth J. Olivier Jr., Sara A. Hurvitz

By Kenneth J. Olivier Jr., Sara A. Hurvitz

Providing functional and confirmed strategies for antibody-drug conjugate (ADC) drug discovery luck in oncology, this ebook is helping readers increase the drug protection and healing efficacy of ADCs to kill detailed tumor cells.

• Discusses the fundamentals, drug supply recommendations, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case reviews of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC examine and development

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Extra info for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Sample text

10 Goldenberg DM, Kim EE, DeLand FH, Bennett S, Primus FJ. 11 12 13 14 15 16 17 18 19 20 Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Research 1980;40:2984–92. Antibody‐guided irradiation of malignant lesions: three cases illustrating a new method of treatment. A report from the Hammersmith Oncology Group and the Imperial Cancer Research Fund. Lancet 1984;1:1441–3. US Food and Drug Administration. 1997. ) McLaughlin P, Grillo‐Lopez AJ, Link BK, et al.

The idea that conventional chemotherapeutic drugs were not potent enough to serve as payloads for ADCs has guided much of the subsequent research in the field [4–6]. 2 ­The Building Blocks of a Typical ADC All three parts of an ADC, the antibody, the cytotoxic payload, and the linker chemistry that joins them together, are important in designing an ideal ADC. The design goal is to add the potent tumor cell-killing mechanism afforded by the payload, while retaining all the favorable properties of the antibody in terms of in vivo pharmacokinetics and biodistribution, together with any intrinsic biologic activity and immunologic properties.

Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti‐HER2 monoclonal antibody in women who have HER2‐overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 1999;17:2639–48. FDA Approval Letter for Alemtuzumab. 2001. ) Historical Perspective: What Makes Antibody–Drug Conjugates Revolutionary? 21 US Food and Drug Administration FDA Approves Erbitux for Colorectal Cancer.

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