By Thomas M. Bell (Auth.)
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Pereira, H. G. (1960) Nature, 186, 571. Klemperer, H. , Pereira, H. G. (1959) Virology, 9, 536. Rhim, J. , Jordan, L. , Mayor, H. D. (1962) Virology, 17, 342. , Ishida, N. (1963) Virology, 20,405. CHAPTER SEVEN VIRAL INTERFERENCE AND ANTI-VIRAL SUBSTANCES THE discovery of interferon1 suggested a new approach to the problem of curing virus diseases. Among the most effective chemotherapeutic agents in bacterial infections are the antibiotics which are the byproducts of microbial growth. It is therefore only natural to hope that some byproduct of viral growth might eventually be developed as an effective anti-viral substance.
The application of interferon to the treatment of viral infections is just commencing and much can still be expected from this approach, although a great deal will have to be done before antiviral agents are in regular effective use against those diseases caused by viruses. 1. 2. 3. 4. , Lindenmann, J. (1957) Proc. Roy. Soc. 147, 258. Hoskins, M. (1935) Amer. J. Trop. Med. 15, 675. Pereira, H. G. (1960) Virology, 11, 590. Anderson, K. (1942) Amer. J. Path. 18, 577. VIRAL INTERFERENCE AND ANTI-VIRAL SUBSTANCES 51 5.
Amer. Pub. Health Assoc. Salk, J. , Youngner, J. , Ward, E. N. (1954) Amer. J. Hyg. 60, 214. Lipton, M. , Steigman, A. J. (1955) Proc. Soc. Exp. Biol. Med. 88,114. Johnston, P. , Grayston, J. , Loosli, C. G. (1957) Proc. Soc. Exp. Biol. Med. 94, 338. , Coleman, V. R. (1952) /. Immunol. 68, 645. , Strickland, A. G. R. (1956) Virology, 2, 162. Porterfield, J. S. (1960) Bull. Wld. Hlth. Org. 22, 373. Daniels, J. , Ratner, J. , Brown, S. R. (1961) Science, 133, 640. SEROLOGY 17. 18. 19. 20. 21. 22.